Dinner Time for Obesity and Prediabetes
Johns Hopkins University
Summary
Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.
Description
This is a randomized, cross-over study that examines the metabolic impact of early vs late dinner, as defined by proximity of food intake to an individual's biological night as determined by dim light melatonin onset (DLMO) in normal-weight, healthy adult volunteers and in adults with obesity and prediabetes. Each participant will first undergo circadian phenotyping at the Johns Hopkins Bayview Clinical Research Unit (Baltimore, Maryland), with assessment of DLMO and core body temperature profile, as well as wrist actigraphy. Thereafter, participants will be crossover randomized to (1) a 24-ho…
Eligibility
- Age range
- 18–50 years
- Sex
- All
- Healthy volunteers
- Yes
The investigators are enrolling both Normal-Weight Healthy (NWH) and Obesity-Prediabetes (OPD) research participants. Inclusion Criteria: * For the Normal-Weight Healthy (NWH) cohort: Healthy male and female adults, age 18-50, with BMI 18-24.9 kg/m2 inclusively * For the Obesity-Prediabetes (OPD) cohort: Male and female adults, age 18-50, with BMI ≥30 kg/m2 and prediabetes * All participants must be able to understand study procedures, to comply with the procedures for the entire length of the study and be fully mobile. Exclusion Criteria: * Sleep disorder including insomnia, untreated mod…
Interventions
- BehavioralEarly Dinner
Dinner before DLMO
- BehavioralLate Dinner
Dinner after DLMO
- DrugEarly Dinner tracer
Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner before DLMO
- DrugLate Dinner tracer
Stable isotope of oral \[2H31\] palmitate to measure fat oxidation, given with dinner after DLMO
Locations (2)
- Johns Hopkins Bayview Medical CenterBaltimore, Maryland
- National Institutes of Health Clinical CenterBethesda, Maryland