Functional Brain Mapping in Pediatric Neurosurgery
Wayne State University
Summary
We aim to determine the clinical utility of 'dynamic tractography': a novel method for visualizing electrical neural transfers that incorporates the underlying white matter tracts and supporting linguistic processing. We will also determine how well objective electrophysiology biomarkers will improve the prediction of language outcomes following epilepsy surgery. This project will ultimately optimize understanding of how the human brain develops its language network dynamics.
Description
We will determine the utility of a novel brain mapping technique for epilepsy presurgical evaluation, referred to as 'six-dimensional (6D) dynamic tractography'. This innovative program animates the rapid neural propagations along MRI-defined, 3D white matter tracts that connect regions supporting cognitive functions. Specifically, it will use event-related high gamma activity to localize the regions supporting specific linguistic functions and compute the velocity and strength of neural propagations based on the latency and amplitude of early neural responses to single-pulse electrical stimul…
Eligibility
- Age range
- 0–21 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Epilepsy surgery with extraoperative intracranial EEG recording with subdural or depth electrodes. Exclusion Criteria: * Patients with a malignant brain tumor, or progressive neurodegenerative or metabolic disorders who are not considered candidates for intracranial EEG recording.
Interventions
- ProcedureEpilepsy surgery
Epilepsy surgery will be performed as a part of the clinical management of patients with drug-resistant epilepsy.
Locations (2)
- Children's Hospital of MichiganDetroit, Michigan
- Wayne State UniversityDetroit, Michigan