Endometrial Biopsy in Progestin Contraceptive Users
Oregon Health and Science University
Summary
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first year of progestin contraception use. Participants will choose to receive the contraceptive implant (Etonogestrel implant also called Nexplanon) or the contraceptive injectable (Depo-medroxyprogesterone acetate (DMPA) also called Depo-Provera) for up to 12 months. They will be asked to have 4 endometrial biopsies over the course of the study, as well as blood draws, physical exams, and pregnancy tests. Participants will also use a daily text message or email diary to report bleeding patterns. This study's plan is to comprehensively phenotype bleeding patterns and profile the entire endometrium using single-cell RNA seq data (sCRNAseq).
Eligibility
- Age range
- 18–40 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * 18-4 0 years of age at time of enrollment in good general health * Regular menstrual cycles (25-35 day cycle length with bleeding 8 days or less) * Body Mass Index of 19-35 * Confirmed ovulation with a screening serum progesterone of greater than 3ng/mL * No contraindications to DMPA or hormonal implant Exclusion Criteria: * Hormonal or intrauterine contraceptives or other hormone use prior to start of study enrollment \[No oral hormonal contraceptives or other hormones for at least one month, no implantable contraceptives or hormonal or non-hormonal intrauterine devic…
Interventions
- DrugDMPA
The participant will receive the contraceptive injectable, Depo-Provera at the enrollment visit and at 3, 6, 9, and 12 months. Participants will have endometrial biopsies at the enrollment visits and at 3, 6, and 12 months.
- DrugEtonogestrel implant
The participant will receive the contraceptive implant, Nexplanon at the enrollment visits and have endometrial biopsies at the enrollment visits and at 3, 6, and 12 months.
Location
- OHSUPortland, Oregon