Association Between Early Candida Infection (Oral Thrush) and Severe Early Childhood Caries (S-ECC)
Temple University
Summary
The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).
Description
The overall goal of this study is to conduct a longitudinal observational study to investigate the association of early OPC with the onset and severity of S-ECC to better understand the role of Candida (particularly C. albicans) in severe childhood caries. The investigators will test the hypothesis that OPC is associated with S-ECC by modifying the plaque microbiota and enhancing virulence in a manner that is conducive to the early development of the disease. For this study, a total of 70 infants (aged 9-15-month-old) with or without a history of OPC in their first year of life will be enroll…
Eligibility
- Age range
- 0–2 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Male or female individuals at the age of 9-24-month-old * Must have at least one fully erupted tooth at baseline visit * Parent/guardian willing and able to provide informed consent * With or without a history of OPC (the study team will enroll 35 participants with and 35 participants without a history of OPC) Exclusion Criteria: * Presence of a systemic medical condition (e.g. Down syndrome etc.) * Presence of an orofacial deformity * Presence of dental caries * Use of systemic antimicrobial therapy within 30 days of the baseline visit * Presence of any condition whic…
Location
- Temple UniversityPhiladelphia, Pennsylvania