The Bone, Exercise, Alendronate, and Caloric Restriction Trial

Summary

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.

Description

Eligibility

Age range

60+ years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  Bisphosphonate

  Medicine used to treat bone problems, called osteopenia or osteoporosis.

• Behavioral
  Resistance Training/Bone-Loading Exercise

  Exercise in small groups three days per week under the supervision of exercise physiologists. Heart rate and blood pressure will be measured before and after each session and participants will warm-up by walking or cycling for five minutes at a slow pace. All RT exercises will be conducted on machines which accommodate different body sizes and allow small increments in resistance, both important considerations for low functioning older adults with obesity.

• Other
  Placebo

  Capsules identical to the active alendronate capsules without any active ingredients with the same dosing and follow up as BIS treatment group.

Locations (2)