Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer
AdventHealth Translational Research Institute
Summary
To goal of this clinical trial is to quantify the dose-response effects of aerobic exercise training compared to attention control on chemotherapy relative dose intensity in colon cancer survivors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥18 years * Histologically confirmed stage II or III colon cancer * Completed surgical resection with curative intent * Plan to initiate chemotherapy * Engage in \<60 minutes per week of moderate- to vigorous-intensity structured aerobic exercise * No planned major surgery during the study period * Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire * Can walk 400 meters * Can read and speak English * Ability to provide written informed consent * Provide written approval by qualified healthcare professional * Wi…
Interventions
- BehavioralAerobic exercise
Moderate- to vigorous-intensity aerobic exercise
- BehavioralProgressive stretching
Static stretching of eight major muscle groups
Locations (3)
- Kaiser Permanente Northern CaliforniaOakland, California
- AdventHealthOrlando, Florida
- Dana-Farber Cancer InstituteBoston, Massachusetts