Assessment of Microcirculatory Function in Type 2 Myocardial Infarction
Mayo Clinic
Summary
The purpose of this research is to find out if patients with Type 2 Myocardial Infarction (T2MI) without significant epicardial coronary artery disease (CAD) have a greater chance of having coronary microvascular disease (CMD).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Ability to give informed consent * Structurally normal heart (normal LV and RV function, no more than mild valvular heart disease) * For controls: atypical chest pain with indication for CMD testing * For T2MI: meet criteria for T2MI according to the 4th Universal definition of MI (rise/fall of troponin with at least 1 value \>99th centile+ evidence of symptoms or signs of myocardial ischemia) Exclusion Criteria: * Acute coronary event (evidence of plaque rupture, fissure or dissection on coronary angiogram) * Known to have angiographically significant CAD/pressure wir…
Interventions
- Diagnostic TestCoronary angiogram with coronary reactivity testing (CRT)
CRT is an angiography procedure (using X-ray) to examine the small blood vessels in the heart and how they respond to three drugs (adenosine, acetylcholine and nitroglycerin) as per clinical protocol.
Location
- Mayo Clinic RochesterRochester, Minnesota