Bryan Cotton
The purpose of this study is to determine if additional interventions will assist with decreasing the risk and/or severity of thromboembolism (clotting complications) in patients who have experienced a major traumatic event.
Inclusion Criteria: * Admission to trauma service * Polytraumatic injuries OR pelvic/long bone fracture * Planned admission to trauma ICU or step-down/SIMU setting (this includes STICU, SIMU/TIMU, BICU, and BIMU) * Informed consent obtained Exclusion Criteria: * Prisoners (defined as those directly admitted from correctional facility) * Known or suspected pregnancy * ≥ 20% total body surface area (TBSA) burned * Nonsurvivable head injuries * Known hematologic or immunologic disorders * Known prehospital anticoagulant use * Patients initially placed on unfractionated heparin for thromboproph…
Bolus intravenous infusion of Thrombate will be given to achieve antithrombin (AT) activity levels at 150% before the 3rd dose of Enoxaparin. The dose will be based on patient weight.
Normal Saline will be given as one time IV before the 3rd dose of Enoxaparin. The dose will be based on patient weight.