Ohio State University
This study aims to examine the cognitive and neural pathways underlying the joint impact of chemical and social exposures on two aspects of cognitive function: cognitive control and reward processing. The investigators will use high resolution, multi-band resting state and task functional magnetic resonance imaging (fMRI) as well as neuromelanin stain MRI to identify pathways through which exposure to a mixture of prenatal chemical and early life social exposures alters brain function and behavior. Specifically, the investigators will leverage extant prenatal exposure data (N=550) from the Columbia Center for Children's Environmental Health (CCCEH) Mothers and Newborns (MN) birth cohort and study symptoms and brain function in adolescence.
Adolescence is a period of high risk for the emergence of psychiatric issues, particularly attention problems, substance abuse, and psychotic experiences. Risk for these problems likely originates in the prenatal period when the brain undergoes significant rapid change, making this a particularly vulnerable time for alterations in brain development. Few studies have examined risk from prenatal exposure to neurotoxicants that emerge in adolescence and the biological pathways that underlie these associations. Emerging findings suggest that prenatal exposure to environmental chemicals (e.g. envir…
Inclusion Criteria: * Participation in either the Mothers and Newborns or Sibling/Hermanos Cohort * Available prenatal exposure data leveraged from the CCCEH database * Ability of subject or parent to understand and the willingness to sign a written informed consent document. * For children, informed assent and parental informed consent to participate in the study * Males and females; Age 15-23 years old * Adolescents and parents must be English- or Spanish-speaking Exclusion Criteria: * Contraindication for MRI as determined by institutionally approved MRI screening questionnaire
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