Jennifer Crombie, MD
The goal of this research study is to evaluate the combination of study drugs, Glofitamab and Polatuzumab, and a standard chemotherapy regimen, R-CHP, as a treatment for high-risk diffuse large B-cell lymphoma. The names of the treatment interventions involved in this study are: * Glofitamab (T-cell bispecific antibody) * Polatuzumab (antibody-drug conjugate) * R-CHP (a chemotherapy regimen comprised of Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, and Prednisone)
This study is an open-label, multi-center, single-arm phase II study of glofitamab plus polatuzumab and R-CHP for patients with previously untreated high-risk diffuse large B-cell lymphoma (DLBCL). * Study procedures include screening for eligibility, study evaluations, radiological scans of tumors, tumor biopsies, TTE/MUGA scans, and blood collections. * All participants will receive two cycles of polatuzumab -R-CHP and four cycles of glofitamab- polatuzumab -R-CHP. After completion of chemotherapy patients will receive two additional cycles of glofitamab alone. * Participants receive s…
Inclusion Criteria: * Previously untreated patients with CD20-positive DLBCL, including one of the following diagnoses by 2016 WHO classification of lymphoid neoplasms * DLBCL, not otherwise specified (NOS) * T-cell/histiocyte-rich large B-cell lymphoma * Epstein-Barr virus-positive DLBCL, NOS * ALK-positive large B-cell lymphoma * HHV8-positive DLBCL, NOS * High-grade B-cell lymphoma (HGBCL), NOS * HGBCL with translocations of MYC and BCL-2, or MYC and BCL-6 * Availability of archival (within 90 days) or freshly collected tumor tissue before study enrollment. If archival tissu…
human IgG1-bispecific antibody, via IV infusion
an antibody drug conjugate (ADC) that contains a humanized IgG1 anti-human CD79b monoclonal antibody, via IV infusion
Per standard care, via IV infusion
Per standard care, via IV infusion
Per standard care, via IV infusion
Per standard care, orally
Arctuva estimate
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