Supraspinal Processing of Sensory Aspects of Pain
Children's Hospital Medical Center, Cincinnati
Summary
The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments
Description
Chronic pain affects approximately 20% of both adults and children in the US and is a source of substantial disability and health care costs. Chronic pain can be challenging to diagnose due to the presence of poorly understood symptoms. When diagnosed, current pharmacologic treatments for pain are remarkably ineffective, while effective non-pharmacologic treatments remain under-utilized. These shortcomings in the diagnosis and treatment of pain arise from tremendous gaps in our knowledge about the basic central nervous system systems that process nociceptive information and instantiate an expe…
Eligibility
- Age range
- 10–17 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Patients will need a diagnosis of a chronic pain derived congruent with ICD-11 criteria related to headache (migraine, daily headache), abdominal (FAPD), localized MSK (single limb/joint, low back or chest pain), diffuse MSK (widespread MSK pain), or CRPS * If on medications, they need to be on stable doses of prescribed pain and/or psychiatric medications for 4 weeks before the baseline study visit. * Male or female, age 10 -17 (inclusive) * English speaking, able to complete interviews and questionnaires in English Exclusion Criteria: * Weight/size incompatible with…
Interventions
- OtherMultisensory Task
Reversing checkerboard, tones, and finger opposition.
- OtherGraphesthesia
Trace numbers on skin.
- OtherDivided attention
Divide attention between two noxious stimuli.
Location
- Cincinnati Children's HospitalCincinnati, Ohio