Trifecta-Lung cfDNA-MMDx Study: Comparing the Dd-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test
University of Alberta
Summary
Demonstrate the relationship between dd-cfDNA levels and HLA antibodies in blood transplant recipient and Demonstrate the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from lung transplants.
Description
The current standard for assessment of rejection in lung transplants is a transbronchial biopsy (TBB) interpreted by histology according to International Society of Heart and Lung Transplantation (ISHLT) guidelines. This has considerable error rates, many due to the high disagreement among pathologists. There is a need for new methods of assessing TBBs. Furthermore, by analyzing different types of biopsies (TBBs and endobronchial - 3BMBs), we hope to improve the safety of the biopsy procedure, while maintaining its accuracy. The emergence of blood donor-derived cell-free DNA (dd-cfDNA) measure…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: Adult, Older adult Exclusion Criteria: Patients will be excluded from the study if they decline participation Are unable to give informed consent. Recipients of multiple organs, cancer patients and pregnant women
Locations (18)
- St. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLTPhoenix, Arizona
- Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, College of MedicineGainesville, Florida
- USF Health, Morsani College of Medicine, 12901 Bruce B. Downs Blvd. MDC40Tampa, Florida
- Indiana University Methodist Hospital 1812 N. Capitol Ave Suite W131LIndianapolis, Indiana
- Johns Hopkins Interventional Pulmonology, Sheikh Zayed Tower, Room 7125L, 1800 Orleans StreetBaltimore, Maryland
- Division of Pulmonary, Allergy & Critical Care Medicine Columbia University Irving Medical CenterNew York, New York