Disentangling the Role of Depression in Hypersomnia
University of Pennsylvania
Summary
Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.
Description
There are often challenges in the diagnosis of Idiopathic Hypersomnia (IH) in patients with comorbid psychiatric disorders, mood disorders in particular, who often report symptoms including excessive sleep duration and daytime somnolence. Further, 15-25% of patients with IH report significant depressive symptoms. When comparing these patients groups, studies have not found significant differences in depression scores, indicating the severity of depression cannot be reliably used to support diagnostic distinctions. These findings present significant challenges to the differential diagnosis of I…
Eligibility
- Age range
- 21–55 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Males and females between the age of 21 and 55 * Meet DSM5 criteria for Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder * Ability to read and speak English Exclusion Criteria: * Unable or unwilling to provide informed consent * Untreated obstructive sleep apnea (apnea-hypopnea index /= 15 events/hr) * Meeting diagnostic criteria for narcolepsy * A clinically unstable medical condition as defined by a new diagnosis or change in medical management in the previous 2 months (e.g., pneumonia, thyroid disease, ventricular arrhythmias, cirrhosis, s…
Interventions
- Diagnostic TestSleep study
Participants will spend two nights in the Penn Sleep Center
Location
- The University of PennsylvaniaPhiladelphia, Pennsylvania