Robert Bok, MD, PhD
This study will investigate the use of hyperpolarized (HP) carbon-13 (13C) alpha-ketoglutarate (aKG) (HP 13C-aKG) to characterize tumor burden in participants with isocitrate dehydrogenase (IDH) mutant glioma.
PRIMARY OBJECTIVES: I. To define the most appropriate imaging parameters for obtaining hyperpolarized 13C-aKG from participants with IDH mutant glioma. II. To assess the safety and feasibility of hyperpolarized 13C-aKG magnetic resonance (MR) metabolic imaging as a new and unique tool for evaluating tumor burden in participants with IDH mutant glioma. OUTLINE: Participants will be assigned to one of 2 cohorts: COHORT 1: Participants with IDH mutant glioma for sequence development. COHORT 2: Participants with recurrent IDH mutant glioma before receiving surgical resection. This imaging s…
Inclusion Criteria: 1\. Participants must be \> 18 years old who have evidence of evaluable disease (with contrast enhancing lesion or non-enhancing lesion \> 1 cubic centimetre (cc)) * Cohort 1: Participants with IDH mutant glioma who may or may not have received prior treatment * Cohort 2: Participants with recurrent IDH mutant glioma before receiving surgical resection, All the subjects must have prior MR scans available for review to assess the location and size of residual/recurrent tumor and do not have contraindication for magnetic resonance (MR) examinations. To be included in the s…
Given intravenously at time of imaging
Magnetic resonance imaging is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body
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