Exercise Response in Humans With Obesity
Mayo Clinic
Summary
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
Eligibility
- Age range
- 20–45 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Obese men and women ≥ 20 and ≤ 45 years of age. Exclusion Criteria: * Diabetes or fasting plasma glucose \>126 mg/dL * Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * Renal failure (serum creatinine \> 1.5mg/dl) * Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine tr…
Interventions
- Diagnostic TestTreadmill Test
Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
- Diagnostic TestStrength Test
Measure the strength of leg muscles by kicking against a machine with resistance.
- Diagnostic TestDual-Energy X-Ray Absorptiometry
Body composition measurement.
- ProcedureMuscle Biopsy
Obtain a small piece of muscles from the upper part of the legs
- ProcedureFat Biopsy
Fat sample taken from abdomen
- Diagnostic TestResting Energy Expenditure
Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
Location
- Mayo Clinic in RochesterRochester, Minnesota