Mayo Clinic
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
Inclusion Criteria: * Obese men and women ≥ 20 and ≤ 45 years of age. Exclusion Criteria: * Diabetes or fasting plasma glucose \>126 mg/dL * Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl) * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment) * Renal failure (serum creatinine \> 1.5mg/dl) * Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine tr…
Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
Measure the strength of leg muscles by kicking against a machine with resistance.
Body composition measurement.
Obtain a small piece of muscles from the upper part of the legs
Fat sample taken from abdomen
Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
MRI on upper leg to look at fat and muscle
Arctuva estimate
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