Effects of Nocturnal Inorganic Nitrate Supplementation on Physiological Function
Mayo Clinic
Summary
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 18-35 or 65-80 years of age Exclusion Criteria: * Coronary artery disease * Heart failure * Pregnancy * Diabetes * Sleep disorders * Shift workers * Individuals who typically go to sleep after midnight * Individuals who traveled across ≥2 time zones within one week of study visits * Individuals with a history frequent kidney stones * BMI ≥35.0kg/m2 * Use of nicotine-containing products within the two years preceding study visits * Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with the nitrate-nitrite-nitric oxide pathway o…
Interventions
- Dietary SupplementActive Beetroot Juice Supplement (aBRJ)
aBRJ will consist of 70ml concentrated beetroot juice with 6.45-7.26mmol inorganic nitrate (range for inter-batch variability) taken orally.
- Dietary SupplementPlacebo Beetroot Juice Supplement (pBRJ)
pBRJ will consist of 70ml concentrated beetroot juice and will be chemically devoid of inorganic nitrate taken orally.
Location
- Mayo Clinic in RochesterRochester, Minnesota