Mayo Clinic
The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.
Inclusion Criteria: * 18-35 or 65-80 years of age Exclusion Criteria: * Coronary artery disease * Heart failure * Pregnancy * Diabetes * Sleep disorders * Shift workers * Individuals who typically go to sleep after midnight * Individuals who traveled across ≥2 time zones within one week of study visits * Individuals with a history frequent kidney stones * BMI ≥35.0kg/m2 * Use of nicotine-containing products within the two years preceding study visits * Use of allopurinol, proton pump inhibitors, or other medications/supplements which interfere with the nitrate-nitrite-nitric oxide pathway o…
aBRJ will consist of 70ml concentrated beetroot juice with 6.45-7.26mmol inorganic nitrate (range for inter-batch variability) taken orally.
pBRJ will consist of 70ml concentrated beetroot juice and will be chemically devoid of inorganic nitrate taken orally.
Arctuva estimate
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