University of California, Los Angeles
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
The overall objective of this placebo-controlled, outpatient study is to compare the dose-dependent effects of smoked and oral THC on analgesia and endpoints directly related to adverse consequences of use including abuse liability, intoxication, and impairment as a function of age and sex.
Inclusion Criteria: * Male or non-pregnant female aged 18-65 years according to the below criteria: EMERGING ADULTS: 18-25 years of age (+/- one year) MIDDLE-AGED ADULTS: 35-45 years of age (+/- one year) LATE MIDDLE-AGED ADULTS: 55-65 years of age (+/- one year) * Report weekly-monthly use of cannabis (with primary mode of use via inhalation) over the past 6 months prior to screening * Not currently seeking treatment for their cannabis use * No reported clinically significant adverse effects with cannabis use * Have a Body Mass Index from 18.5 - 34kg/m2 * Able to perform all study procedures…
smoked cannabis
Oral delta-9-THC
Placebo Cannabis
Oral Placebo
Arctuva estimate
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