Validation of Point-of-care Thromboelastography (TEG 6s) in Pediatric Patients
Indiana University
Summary
The goal of this observational study is to learn about the performance of the TEG6s in normal pediatric patients. The main questions it aims to answer are: What are the normal TEG 6S lab results in normal pediatric patients and how do they compare to existing published reference ranges. Participants and their guardians will be asked to submit a small amount of blood at the beginning of an elective operation for analysis in the TEG 6s machine.
Description
Trauma is the leading cause of death in children. Researchers, starting with Trunkey et al., have described three general time points of mortality after trauma - in the field, early secondary to hemorrhage and late due to infectious complications. Early mortality after trauma is specifically linked to hemorrhage. Trauma-induced coagulopathy is a multifactorial phenomenon present after trauma in both children and adults that can worsen hemorrhage and ultimately lead to increased mortality. Classical laboratory measurements of the coagulation pathway (PT, PTT, INR, fibrinogen, platelet count) ha…
Eligibility
- Age range
- 0–18 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: -Patients less than 18 years of age undergoing elective pediatric surgical care in the operating room at Riley Hospital for Children Exclusion Criteria: * Known disorder of coagulation pathway(s) * Administration of medications that may alter the coagulation cascade * Patients in foster care or wards of the court
Interventions
- Diagnostic TestThromboelastography (TEG 6S)
The TEG 6s assays are performed in a microfluidic cartridge which only requires a small amount of a patient's blood be transferred to the cartridge for analysis. The vibration frequency of the blood meniscus at which resonance occurs is used to create a clot dynamics tracing.
Location
- Riley Hospital for ChildrenIndianapolis, Indiana