Ovarian Tissue Cryopreservation for Fertility Preservation in Patients Facing Infertility-causing Diseases or Treatment Regimens
University of Pittsburgh
Summary
The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation. In addition, this study will provide research tissue for the following Specific Aims: 1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting successful maturation ovarian tissue. Participants will undergo a surgical procedure to remove an ovary (oophorectomy) to preserve their gonadal tissue for fertility preservation.
Description
The cure rate of cancer in children, adolescents and young adults continues to increase with advances in chemotherapy and/or radiation protocols. As more pediatric oncology patients become long-term survivors, the consequences of their treatment on their quality of life have become an important thrust of clinical oncology and basic science research. One of the most common and most devastating long-term sequelae following cancer treatment is infertility. Many chemotherapy and radiation-containing regimens for cancer therapy or prior to bone marrow transplantation can cause sterility in children…
Eligibility
- Age range
- Up to 39 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Be female age less than 40 years old. * Unable or unwilling to make use of oocyte or embryo banking alone. * Be scheduled to undergo surgery, chemotherapy, drug treatment and/or radiation for the treatment or prevention of a medical condition or malignancy with risk of causing permanent and complete loss of subsequent ovarian function. * Or, have a medical condition or malignancy that requires removal of all or part of one or both ovaries. * Or, Have newly diagnosed or recurrent disease. Those who were not enrolled at the time of initial diagnosis (i.e., patients with re…
Interventions
- Diagnostic TestInfectious Disease Labwork
Infectious disease labs will be drawn and resulted.
- Diagnostic TestFertility-Based Labwork
Other labwork to understand fertility may be drawn.
Location
- Magee-Womens HospitalPittsburgh, Pennsylvania