The Effects of Acute and Chronic Exercise on the Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Summary

This clinical trial studies the effect of short-term (acute) and long-term (chronic) exercise on immune characteristics and function (phenotype) of patients with indolent non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). Most newly-diagnosed CLL patients have early-stage disease at the time of diagnosis and do not require treatment. Despite not needing therapy, these patients have significant immune dysfunction. This may lead to an increased risk of serious infections requiring hospitalization and an increased risk of secondary non-blood-based (hematologic) cancers. Increasing CLL patients overall physical fitness levels, through exercise during the observation stage, may provide a realistic approach means to increase survival, decrease treatment-related side effects, and improve immune function. Information learned from this study may help researchers determine whether a particular exercise regimen can be used to strengthen the immune system of indolent NHL and CLL patients, delay time to disease progression, assess the need for treatment, and assess infection rates.

Description

Eligibility

Age range

18–80 years

Sex

All

Healthy volunteers

Yes

Interventions

• Procedure
  Biospecimen Collection

  Undergo collection of blood

• Other
  Cardiopulmonary Exercise Testing

  Undergo CPET

• Procedure
  Dual X-ray Absorptiometry

  Undergo DEXA scan

• Other
  Electronic Health Record Review

  Ancillary studies

• Other
  Exercise Intervention

  Undergo aerobic based training program

• Procedure
  Physical Examination

  Undergo measurement of height/weight and vital signs

• Other
  Questionnaire Administration

Locations (2)