Mayo Clinic
The purpose of this study is to compare IV Acetaminophen for pain control to the usual care with opioids in patients admitted for small bowel obstruction.
The primary aim of this study is to assess the feasibility of conducting a randomized trial involving intravenous acetaminophen for pain control compared to usual care with opioids in patients admitted for small bowel obstruction and to summarize pain scores up to 72 hours after treatment. Patients presented and diagnosed with small bowel obstruction (SBO) will be screened for eligibility and will be offered participation in this study. Patients admitted for SBO for medical management with pain on admission will be eligible to participate in study. This will include patients with malignant and…
Inclusion Criteria: * Small bowel obstruction diagnosed by radiographic study; and * Abdominal pain on admission. * Nothing per mouth diet. * The ability to give appropriate consent or have an appropriate representative available to do so. Exclusion Criteria: * Known liver failure or cirrhosis. * Acetaminophen toxicity on admission. * Known acetaminophen allergy. * Alcohol intoxication on admission. * History of substance abuse. * Creatinine clearance \< 30 (or Creatinine level \> 2). * Liver transplant recipients. * Ileus on admission. * Admitted for surgical intervention for SBO. * Admitt…
1000mg intravenous every 6 hours on day 1 and day 2. 1000mg intravenous every 8 hours on day 3 as needed.
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