A Multicenter Open-label Phase 1 Trial to Evaluate Safety and Preliminary Efficacy of Endovascularly Applied Vascular Targeted Photodynamic Therapy (VTP) for Patients With Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma

Summary

This is a prospective, multicenter, non-randomized, open label light dose escalation phase I trial to evaluate the safety and preliminary efficacy of Padeliporfin vascular targeted photodynamic therapy (VTP) applied via endovascular fiber placement within a dilatation catheter, through the target artery(superior mesenteric artery (SMA), celiac artery (CA) or common hepatic artery (CHA)). The investigators will evaluate safety and preliminary efficacy of Padeliporfin VTP administered endovascularly using light dose escalation.

Description

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Combination Product
  Padeliporfin Vascular Targeted Photodynamic (VTP) therapy

  Vascular targeted therapy (VTP) will be applied via endovascular fiber placement within a dilatation balloon catheter, through the target artery (superior mesenteric artery (SMA), celiac artery (CA) or common hepatic artery (CHA)). The balloon will be inflated to impede blood flow for total of 10 minutes during light illumination

Locations (2)