Neurovascular and Neurocognitive Consequences of Iron Deficiency Anemia
Children's Hospital Los Angeles
Summary
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects. The main purposes of this study is to phenotype the scope of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine derangements in cerebral perfusion, vascular reactivity, functional connectivity, and blood brain barrier permeability in adult-onset IDA and relate them to neurocognitive deficits, as well as determine the reversibility and durability of both the physiologic and neurocognitive derangements by iron replacement therapy. All eligible subjects will be asked to provide informed consent before participating in the study.
Description
This is a trial with an observational and an interventional arm, in patients with moderate to severe anemia and control subjects. The main purposes of this study is to phenotype the scope of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine derangements in cerebral perfusion, vascular reactivity, functional connectivity, and blood brain barrier permeability in adult-onset IDA and relate them to neurocognitive deficits, as well as determine the reversibility and durability of both the physiologic and neurocognitive derangements by iron replacement therapy. All…
Eligibility
- Age range
- 16–60 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Observational arm: 1. Age between 16 and 60 years of age. 2. Any ethnicity. 3. Female 4. Anemic group: hemoglobin ≤10.5 g/dl or hematocrit \<32% from finger prick or plethysmography test, or \<11 g/dl from venipuncture blood draw 5. Control group: hemoglobin \>13.2 g/dl or hematocrit \>39.6% * Interventional arm: 1. Criteria for observational component, plus 2. Iron deficiency anemia based upon attending hematologist interpretation of transferrin saturation, ferritin, and other ancillary labs including hs-CRP, MMA, hemoglobin electrophoresis Exclusion Cr…
Interventions
- DrugFerric derisomaltose
Refer to arm/group descriptions
- DrugNovaFerrum
Refer to arm/group descriptions
Locations (4)
- City of Hope Blood Donor CenterDuarte, California
- Cedar Sinai Blood BankLos Angeles, California
- Children's Hospital Los AngelesLos Angeles, California
- University of California, Los Angeles Blood Donor CenterLos Angeles, California