Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults
Yale University
Summary
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
Description
The investigators will examine the influence of cooling components of WS-3, WS-23 (synthetic coolants) and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults. Participants will rate the flavor intensity, coolness, sweetness, and irritation/harshness, bitterness experienced using validated rating scales. 66 adult participants (18+ years of age) who are current e-cigarette users will participate in 3 laboratory sessions. Participants will be randomized to receive one of the 3 menthol conditions (no-menthol, low menthol, high menthol) in Lab 1 and will rec…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 18 years or older * Able to read and write * Some current e-cigarette use * Urine cotinine ≥200ng/ml * Willing to abstain from tobacco/nicotine use 2 hours prior to sessions Exclusion Criteria: * Current use of non-prescription substances besides nicotine, marijuana, alcohol * Any significant current medical or psychiatric condition * Known hypersensitivity to propylene glycol * Pregnant or lactating females * Uncontrolled asthma * Nut/e-liquid flavorant allergy * Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI)…
Interventions
- OtherE-liquid coolant (No WS-3) for non-menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
- OtherE-liquid coolant (No WS-3) for low (0.1%) menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
- OtherE-liquid coolant (No WS-3) for high (2.0%) menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
- OtherE-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
- OtherE-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
Location
- JB Pierce LabNew Haven, Connecticut