Study detail

RecruitingObservational

Examining Appeal and Addiction Potential of Novel E-cigarette Constituents Among Adults

Yale University

Summary

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Description

The investigators will examine the influence of cooling components of WS-3, WS-23 (synthetic coolants) and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults. Participants will rate the flavor intensity, coolness, sweetness, and irritation/harshness, bitterness experienced using validated rating scales. 66 adult participants (18+ years of age) who are current e-cigarette users will participate in 3 laboratory sessions. Participants will be randomized to receive one of the 3 menthol conditions (no-menthol, low menthol, high menthol) in Lab 1 and will rec…

Eligibility

Age range: 18+ years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * 18 years or older * Able to read and write * Some current e-cigarette use * Urine cotinine ≥200ng/ml * Willing to abstain from tobacco/nicotine use 2 hours prior to sessions Exclusion Criteria: * Current use of non-prescription substances besides nicotine, marijuana, alcohol * Any significant current medical or psychiatric condition * Known hypersensitivity to propylene glycol * Pregnant or lactating females * Uncontrolled asthma * Nut/e-liquid flavorant allergy * Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI)…

Interventions

Other
E-liquid coolant (No WS-3) for non-menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
Other
E-liquid coolant (No WS-3) for low (0.1%) menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
Other
E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.
Other
E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.
Other
E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)
Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.

Location

JB Pierce Lab
New Haven, Connecticut

E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.

Other

E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

Other

E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

Other

E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

Other

E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

Other

E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

Other

E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

Other

E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

Other

E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

Other

E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

Other

E-liquid coolant (4% WS-23) for non-menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

Other

E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

Other

E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

Compensation

Estimated

~$10 – $6,250

Arctuva estimate

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Details

NCT ID: NCT05932745
Type: Drug
Last updated: 6/16/2026

Summary

Description

Eligibility

Interventions

Location

Compensation

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Details

Conditions