University of Maryland, Baltimore
The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal Alzheimer's disease) and with healthy aging. Findings from this pilot project will guide and refine the development of a future larger clinical trial that aligns with the goals of the National Alzheimer's Plan of Action (NAPA), especially regarding "Prevent and Effectively Treat Alzheimer's Disease (AD) by 2025.
Inclusion Criteria: * Adult men and women of all races and ethnicities who are 50-80 years of age will be eligible. * Only sedentary adults will be eligible (engaging in structured activity for exercise \<3x/week) for Progressive aerobic exercise or Combined training * Ability to use, and accessibility to, an iPad or computer is required for the Adaptive cognitive training and Combined training. * Fluent in English. * The diagnosis of MCI will first be confirmed at the screening evaluation using the clinical dementia rating (CDR) scale and the Montreal Cognitive Assessment (MoCA). We will als…
Progressive aerobic exercise
Adaptive cognitive training
Combine adaptive cognitive and progressive aerobic exercise training
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