Northwestern University
The purpose of this study is to assess whether TNFa antibody use before lung transplant can prevent kidney injury after lung transplant.
After being informed about the study and potential risks, all patients giving written consent who undergo a lung transplant will be randomized in a 1:1 ratio to either the treatment or control group. Patients randomized to the treatment group will receive one dose of the study drug, Etanercept, via subcutaneous injection just prior to the lung transplant. Patients randomized to the control group will not receive Etanercept. Both groups will receive standard lung transplant care after implantation.
Inclusion Criteria: * Planning to undergo transplantation of the lung at Northwestern Memorial Hospital. * Willing and able to read, understand, and be capable of giving informed consent. Exclusion Criteria: * Previous or current use of TNFa antibody. * Positive virtual or retrospective crossmatch or highly sensitized (pRA \> 30%) recipients. * Any condition that, in the opinion of the attending physician, would place the patient at undue risk by participating.
25 mg subcutaneous injection
Arctuva estimate
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