School Inner City Air Study
Massachusetts General Hospital
Summary
The goal of this randomized clinical trial is to test the efficacy of high efficiency particulate air (HEPA) cleaners in reducing respiratory viral exposure and infections in elementary school classrooms. Classrooms will be randomized to active vs. sham HEPA cleaners. The main questions it aims to answer are: * Do classroom HEPA cleaners reduce exposure to viruses? * Do classroom HEPA cleaners reduce student and teacher infections? * Do classroom HEPA cleaners reduce infections in family members?
Description
Classrooms from participating schools will be randomized to active vs. sham HEPA cleaners. From enrolled classrooms, we will enroll students, teachers, and members of the household. We will collect the following: * longitudinal classroom air samples * longitudinal upper respiratory samples * longitudinal symptom surveys using the Wisconsin Upper Respiratory Symptom Survey (WURSS) Viral testing on collected air and respiratory samples will be performed using digital polymerase chain reaction (dPCR).
Eligibility
- Age range
- 6–90 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Children * Grades K-5 (age 6-12 years) * Attend one of the schools that the study team has permission to obtain classroom/school environmental samples * Have no plans to move schools within the upcoming 12 months * Subject and/or parent guardian must be able to understand and provide informed consent and also willing to participate in the study Adults * Adult (age 21 or older) parent, caretaker, or household member of child participating in this study, or teacher in classroom participating in study * Able to understand and provide informed consent Exclusion Criteria:…
Interventions
- OtherActive classroom HEPA cleaner
Commercially available portable HEPA cleaner
- OtherSham classroom HEPA cleaner
Commercially available portable HEPA cleaner with filtration device removed
Location
- Mass General BrighamBoston, Massachusetts