The Role of Thomboxane A2 and it's Receptor in Vascular Regulation in Women With Endometriosis
Penn State University
Summary
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.
Description
Cardiovascular disease (CVD) is the leading cause of death worldwide. Endometriosis is an independent risk factor for CVD that affects an estimated one in ten women in the world. Endometriosis is a gynecologic condition characterized by invasive extrauterine endometriotic lesions, chronic pain, and systemic inflammation. The expression of thromboxane A2 (TxA2), a product of the inflammatory cyclooxygenase pathway, is upregulated in endometriotic lesions. In the vasculature, TxA2 blocks vasodilation, and induces vasoconstriction. TxA2 diffuses across the innermost layer of cells in the blood ve…
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Born with a uterus * 18-45 years old * With and without endometriosis Exclusion Criteria: * Currently pregnant or breastfeeding * Diagnosed cardiovascular disease * BMI over 35 * Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.) * Currently using hormone replacement therapy (or have used within previous 6 months) * Known skin allergies or current rash, skin disease, disorders of pigmentation * Diabetes * Renal disease, renal artery stenosis, renal impairment * Liver disease * Stage II Hypertension (blood pressure \>140/\>90 mmHg) * Hypotension (blood pressure…
Interventions
- DrugAspirin
650 mg aspirin (Acetylsalicylic acid)
- OtherPlacebo
placebo capsule
Location
- Noll LaboratoryUniversity Park, Pennsylvania