Mechanisms Underlying the Variation in Rate and Levels of Gingival Inflammatory Responses Among the Human Population
University of Washington
Summary
The aim of this NIH National Institute of Dental and Craniofacial Research (NIDCR) funded study is to identify molecular mechanisms underlying observed variations in human responses to natural accumulation and maturation of dental plaque.
Description
This study will employ the split-mouth Experimental Gingivitis model where healthy study participants are asked to abstain from oral hygiene on a select set of teeth (test teeth) for a period of 21 days. The study consists of 3 phases; Hygiene Phase (Day -14-0), Experimental Induction Phase (Day 0-21), and Resolution Phase (Day 21-35). Abstaining from oral hygiene on the test teeth will result in the natural accumulation and maturation of dental plaque (a bacterial biofilm) on the tooth surface which will in induce a host inflammatory response. By investigating the onset of microbially induced…
Eligibility
- Age range
- 18–35 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Provide signed and dated informed consent form * Willing to comply with all study procedures and be available for the duration of the study * Male or female, aged 18-35 years * Good general health, ASA I (healthy with no systemic conditions) * No clinical signs of gingival inflammation at \> 90% of sites observed (whole mouth) (\< 10% of sites with GI of \< 2 and no sites with a score of 3; \< 10% sites with BOP +). * Probing depth (PD) ≤ 3.0 mm (Whole Mouth) * Attachment loss (AL) = 0 mm (Whole Mouth) * Gingival health at Visit 2 (Day 0) for study sites (Test/Control te…
Interventions
- BehavioralAbstinence of oral hygiene on select teeth
Study participants abstain from oral hygiene on a select set of four teeth for a period of 21 days
Location
- University of WashingtonSeattle, Washington