Visual Function as a Novel Outcome Measure Following Neonatal Hypoxic Ischemic Encephalopathy
University of Wisconsin, Madison
Summary
The purpose of this research study is to gather more information on how eye injury is related to a baby's future development and see if eye function and brain test results can be used, along with current measures, to better diagnose and treat babies with hypoxic-ischemic encephalopathy (HIE). Participants will undergo up to two eye exam sessions, involving both Visual Evoked Potential (VEP) and Electroretinogram (ERG) exams.
Description
Specific Aims/Study Objectives: In this proposed longitudinal study, the investigators hypothesize that the early visual function findings will correlate with the neurodevelopmental and neuroimaging outcomes in children who sustain HIE. The investigators will test this hypothesis through the following specific aims: * Specific Aim 1 will determine the correlation of the ERG results as a measure of the retinal function obtained at around birth, 3, 9, 18 or 30 months of life and neurodevelopmental-neuroimaging outcomes from birth through 36 months. * Specific Aim 2 will determine the correlati…
Eligibility
- Age range
- Up to 3 years
- Sex
- All
- Healthy volunteers
- Yes
HIE Neonate Inclusion Criteria: * Inpatient Neonates diagnosed with HIE * Pediatric patients who are less than 78 hours of age at the time of enrollment * Participants whose parent/legal guardian is able to complete consenting process in English HIE Neonate Exclusion Criteria: * Participants with prenatally diagnosed or congenital brain and/or eye abnormalities not associated with HIE, including but not limited to microphthalmia, anophthalmia, congenital cataract, eye or eyelid coloboma, congenital glaucoma, CMV retinitis, optic nerve hypoplasia, aniridia, cryptophthalmos, globe abnormaliti…
Interventions
- DeviceVisual Evoked Potential (VEP)
Small gold-cup electrodes will be placed on the participant's head using a small dot of adhesive paste. The handheld device is then connected to the electrodes, and the participant's eyes are exposed to a light flicker. Each eye will be tested separately, and while testing one eye, the other eye may be patched.
- DeviceElectroretinogram (ERG)
Skin electrodes will be placed under each eye. Eyes will then be exposed to a flashing light. Each eye will be tested separately and while testing one eye, the other eye may be patched.
Location
- University of WisconsinMadison, Wisconsin