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56 recruiting studies matching your filters

The HIEnome Study: Genome Sequencing for Perinatal HIE

Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenata…

Hypoxic Ischemic Encephalopathy of NewbornHypoxic Ischemic EncephalopathyHypoxic Ischemic Encephalopathy (HIE)

Estimated

~$10 – $6,250

Baylor College of MedicineNCT06762795

An Early Feasibility Study for the Development of a Model to Non-Invasively Estimate Intracranial Pressure (ICP) and New Metrics of Cerebral Autoregulation (CAR) Using the CoMind One EFS Device

The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help furth…

Intracranial PressureIntracranial Pressure ChangesTraumatic Brain Injury+6 more

Estimated

~$10 – $1,050

CoMind Technologies LimitedNCT06368648

Observational

Late Evening and Early Morning Protein Supplement to Reduce Readmissions for Hepatic Encephalopathy

Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy …

Hepatic Encephalopathy

Estimated

~$10 – $6,250

The Cleveland ClinicNCT04096014

COOLPRIME: Comparative Effectiveness for Cooling Prospectively Infants With Mild Encephalopathy

To determine effectiveness of therapy to improve neurodevelopmental outcomes in infants with mild HIE. To determine the adverse effects of Therapeutic Hypother…

Mild Hypoxic Ischemic Encephalopathy of Newborn

Estimated

~$10 – $750

University of Texas Southwestern Medical CenterNCT04621279

Phase 1

A Phase 1/2, First-in-Human Safety and Proof-of-Concept Study to Evaluate EGEN-5784 Porcine Liver (Drug Product) in Combination With the Metra® Extra-Corporeal Liver Cross-Circulation System in Participants With Acute-on-Chronic Liver Failure

This is a Phase 1/2, first-in-human (FIH) safety, proof-of-concept, two-part study of the genetically-engineered EGEN-5784 liver in combination with the metra®…

Acute on Chronic Liver Failure (ACLF)Hepatic Encephalopathy (HE)

Estimated

~$10 – $8,750

eGenesis, INCNCT07429838

Phase 2

Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia: A Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate Safety and Efficacy (Phase II Study)

Around the time of birth, some babies experience a condition called asphyxia, which means that their brain and other organs do not receive enough blood and/or …

Neonatal Encephalopathy

Estimated

~$10 – $7,500

Pia WintermarkNCT06098833

Observational

Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals With Neurodegenerative Disease

The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative d…

Neurodegenerative DiseasesLeukodystrophyAtaxia+5 more

Estimated

~$10 – $8,750

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.NCT05443906

Biofluid Research on Age-Related or Inherited Neurodegeneration (BRAIN)

The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history informat…

Frontotemporal Degeneration (FTD)ALS (Amyotrophic Lateral Sclerosis)Primary Progressive Aphasia (PPA)+12 more

Estimated

~$10 – $750

University of PennsylvaniaNCT07798700

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

Background: \- Progressive multifocal leukoencephalopathy (PML) is a severe viral infection of the brain. It is caused by JC virus. Many people have this viru…

Progressive Multifocal Leukoencephalopathy

Estimated

~$10 – $675

National Institute of Neurological Disorders and Stroke (NINDS)NCT01730131

Prospective Study of the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Background: Pyrimidine and purine metabolism disorders (DPPMs) affect how the body metabolizes chemicals called pyrimidines and purines. DPPMs can cause dysfu…

AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more

Phase 1

Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning

Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if n…

Carbon Monoxide PoisoningCarbon Monoxide IntoxicationCarbon Monoxide Encephalopathy+1 more

Estimated

~$10 – $6,250

University of NebraskaNCT06574048

Phase 1

A Phase Ib/II First-in-human, Multicentre, Open-label, Multiple Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effect of Intrathecal S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Study CL1-230815-001 (KANDLE) is a Phase Ib/II, First In Human, multicentre, open-label, multiple ascending dose study to assess the safety, tolerability, phar…

Epileptic Encephalopathy

Estimated

~$10 – $7,500

Institut de Recherches Internationales ServierNCT07227857