Breathing Rescue for SUDEP Prevention (BreatheS)
The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * diagnosis of intractable focal epilepsy * admitted to the Epilepsy Monitoring Unit (EMU) at Memorial Hermann-Texas Medical Center for intracranial subdural strips, grids, or depth electrode placement study (invasive video-EEG) Exclusion Criteria: * respiratory, cardiac or cerebrovascular disease * pregnancy * prisoners
Interventions
- OtherBreathing tasks
Breathing tasks include normal breathing through nose or mouth, breathing while resting wakefully, increase and decrease in breathing rate, and breath counting.
- DeviceBrain mapping with stimulation
Electrical stimulation will be used to find specific areas of the brain involved in breathing function. Stimulation will be applied using a Nihon Kohden MEE-1000A neural function measuring system with the MS-120BK extension unit for brain stimulation.
Location
- The University of Texas Health Science Center at HoustonHouston, Texas