Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Washington University School of Medicine
Summary
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria Each patient must meet all of the following criteria: 1. Aged 18 years or older 2. Undergoing elective non-cardiac surgery expected to last ≥ 60 min requiring general anesthesia with a tracheal tube or laryngeal mask airway (or similar supra-glottic device) Exclusion Criteria Patients will not be enrolled if any of the following criteria are met: 1. Inability to provide informed consent in English (at all study sites) or Spanish (at sites where Spanish consent is provided as an option) 2. Pregnancy (based on patient report or positive test on the day of surgery) 3. Surg…
Interventions
- OtherAnesthetic technique Propofol TIVA
Propofol TIVA no inhaled agent
- OtherAnesthetic technique inhaled agent
Must administer inhaled agent.
Locations (20)
- University of Arkansas for Medical Sciences (UAMS)Little Rock, Arkansas
- University of California San FranciscoSan Francisco, California
- Stanford UniversityStanford, California
- Yale School of MedicineNew Haven, Connecticut
- Massachusetts General HospitalBoston, Massachusetts
- Brigham & Women'sBoston, Massachusetts