REcovery From DEXmedetomidine-induced Unconsciousness
Massachusetts General Hospital
Summary
This pilot study in healthy volunteers aims to determine if biological sex has an impact on recovery from dexmedetomidine-induced unconsciousness, and if transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can be used to measure brain complexity during dexmedetomidine sedation without arousing study participants.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Between the ages of 18 to 65 * Normal body weight and habitus, body mass index (BMI) 18 to 30 kg/m2 * Non-smoker * No history of taking stimulants or substance abuse * For women: either use of hormonal contraception, or \> 45 years old and last menstrual period \> 12 months ago in the absence of any contraceptives. * American Society of Anesthesiologists (ASA) physical status classification 1 (ASA 1) * Fluent in English (sufficient to communicate with the study team and understand the consent form) Exclusion Criteria: * Neurologic: epilepsy or positive history of a sei…
Interventions
- DeviceTranscranial Magnetic Stimulation-Electroencephalography
Transcranial magnetic stimulation of the cerebral cortex and measurement of TMS-evoked potentials in the EEG.
Location
- Massachusetts General HospitalBoston, Massachusetts