Uncover Mechanisms Underlying the Development of Chronic Lung Sequelae Post COVID-19
Mayo Clinic
Summary
The purpose of this study is to understand why some people experience long term effects, such as shortness of breath and fatigue, after a severe COVID-19 infection
Description
Each participant will be in the study for approximately 12 months and will be required to come to Mayo Clinic for 3 visits. These visits will take place approximately 2-3 months after confirmed COVID-19 diagnosis (visit 1), 6 months after diagnosis (visit 2), and 12 months after diagnosis (visit 3). Comprehensive clinical evaluation and symptom characterization, quantitative lung CT image analysis and pulmonary function testing, and quality of life questionnaires will be obtained at each visit. Bronchoscopy with BAL (collected at visits 1 and 3 only) and blood samples (collected at all visits…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: For the Sequelae Group * Age ≥18 years at screening, PCR confirmed COVID19 illness (+PCR defines day 0 of illness), hospitalization for COVID-19, absence of pre-existing history of interstitial lung disease, or significant other lung disease. * Severity of illness will be categorized as moderate disease (supplemental oxygen need 1-8L at any time during hospitalization), severe disease (need for high flow oxygen delivery ≥8L at any time during hospitalization) and critical illness (need for ICU admission or mechanical ventilation). Control Recovery Group * Age ≥18 years…
Interventions
- ProcedureBronchoscopies and Bronchoalveolar Lavages (BALs)
Bronchoscopies use a thin, lighted tube, which enters through the mouth or nose and moves down the throat to the airways to look at the lungs. BALs are done during bronchoscopies to collect samples from the lungs for testing. During this procedure, a saline solution is put through the tube to wash the airways and collect a fluid sample.
- Diagnostic TestChest Tomography (CT)
X-ray to create images of the bones and internal organs of the body
- Diagnostic TestElectrocardiogram (ECG)
Measures the electrical activity of the heart by using sticky pads that are placed on your chest and limbs.
- Diagnostic TestPulmonary function tests (PFTs)
Testing to measure how well lungs are working
- Diagnostic Test6 minute walk test (6MWT)
Walking test to see how well the lungs function with exercise over 6 minutes
Location
- Mayo Clinic MinnesotaRochester, Minnesota