Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV (HEALTH-Cog)
University of Alabama at Birmingham
Summary
People aging with HIV are at higher risk for Alzheimer's disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implications for development of personalized approaches for the treatment and prevention of cognitive impairment and dementia in older people with HIV.
Description
The population of people with HIV (PWH) is aging, and are at higher risk for Alzheimer's disease and related dementias (ADRD) than seronegative counterparts. Although physical activity (PA) is a promising protective factor to mitigate ADRD risk, few well-powered PA intervention studies have rigorously tested cognitive outcomes among older PWH, a population with rates of moderate to vigorous PA well below recommended guidelines. Further, given that adherence to habitual PA diminishes after supervised interventions, identifying mechanisms of adherence (MoA) to habitual PA among older PWH is germ…
Eligibility
- Age range
- 50–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Confirmed HIV * Sedentary lifestyle, defined as self-reported PA that breaks a sweat \<3 days/week, with no regular resistance exercise for 3 months preceding study; * Fatigued (≥2.0 on either of the first two screening items on the HIV-Related Fatigue Scale) * On a current, contemporary ART regimen for \>=12 months; * HIV-1 RNA \<200 copies/mL in the past 12 months (assessed via medical records) * Willing to engage in a supervised exercise program 3 times/week for 4 months * Cell phone or email to accept messages * Weight \<450 lbs * Medical clearance by study healthcar…
Interventions
- BehavioralPhase 1 Gym Exercise HIIT
Following a 5-minute warm-up at 50% VO2peak, high and moderate-intensity exercise bouts alternate, progressing to five bouts of 4-minute high-intensity exercise (90% VO2peak), alternating with four 3-minute bouts of moderate-intensity exercise (50% VO2peak) by week 8, followed by a 5 minute cool-down. The total exercise time is 42 minutes.
- BehavioralPhase 1 Gym Exercise CME
Following a 4 minute warm-up at 50% VO2peak, the participant walks for up to 42 continuous minutes at 60% VO2peak172, followed by a 4 minute cool-down. The total exercise time is 50 minutes.
- BehavioralPhase 2 Home Exercise Coaching Text Messages
The coaching intervention will consist of daily text messages tailored to the individual participant's self-reported symptom experiences and barriers to exercise on that specific day. One daily message with a survey will be sent, and responses to survey items will determine the subsequent once daily motivational message.Tailored messages address a range of possible barriers to adherence based on past research, and will provide advice and guidance. Text messages will be varied each week so that even if participants continue to report the same barriers they receive different text messages.
- BehavioralPhase 2 Home Exercise Control Text Messages
The control group will receive general daily texts from the study team (i.e., "Hope you are doing well!"), and reminding them of their next study appointments. These text messages are primarily social/generic in content and serve to maintain involvement and enhance retention of the control group.
Locations (3)
- University of Alabama at BirminghamBirmingham, Alabama
- University of Colorado DenverAurora, Colorado
- University of WashingtonSeattle, Washington