University of Kansas Medical Center
This trial evaluates how inhalational anesthesia (drawn in through the lungs) and total intravenous anesthesia (TIVA) (through a needle in a vein in the arm) change the body's ability to recover from surgery or whether they impact the immune system immediately after surgery in patients with colon cancer. It is unknown whether these types of anesthesia change recovery from surgery or change the chances cancer comes back following surgery. This study may help researchers learn how different types of anesthesia affect recovery from colon cancer surgery.
PRIMARY OBJECTIVE: I. To evaluate the differential impact of TIVA versus inhaled anesthesia on neutrophil extracellular traps (NET) inflammation and immunosuppression among patients undergoing cancer surgery. SECONDARY OBJECTIVES: I. To evaluate the differential impact of TIVA versus inhaled total anesthesia choice on patient reported post-operative recovery: Ia. Overall, and domain-specific post-operative recovery (as measured by the Quality of Recovery Score \[QoR\]-40) on the day of discharge and other post-operative timepoints; Ib. Changes in overall and domain-specific post-operative…
Inclusion Criteria: * Ability of participant OR Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent * Males and females age \>= 18 years on day of consent * Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2 * Patients undergoing resection for biopsy proven colon adenocarcinoma * Medically fit for colon resection * Ability to complete required study questionnaires * Stated willingness to comply with all study procedures and availability for the duration of the study Exclusion Criteria: * Diag…
Undergo blood and tissue sample collection
Ancillary studies
Given via injection
Given IV
Ancillary studies
Given via inhalation
Undergo SOC surgery
Arctuva estimate
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