Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
University of California, San Francisco
Summary
This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.
Description
This is an interventional pharmacokinetic study comparing the uptake and metabolism of nicotine from smoke-exposed clothing in people with low high levels of dermal melanin and people with high levels of dermal melanin. The study will measure nicotine and metabolites of nicotine in the blood during exposure and in urine for 10 days after exposure.
Eligibility
- Age range
- 18–50 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Adult nonsmoker * Aged 18-50 * Skin reflectance scores below 150 or above 249 using the Mexameter 18 instrument * Healthy on the basis of medical history * Systolic blood pressure \<150 * Diastolic blood pressure \<100 * C-reactive protein \<3.1 mg/ml * Liver function (AST and ALT) in normal ranges * kidney function (BUN) in normal ranges * LDL\<131 * Blood glucose \<110 * Not exposed to tobacco SHS. Exclusion Criteria: * Dermal skin reflectance score between 150 and 249, as measured by the Mexameter 18 instrument. * Positive SARS-CoV-2 antibody test * Age 18 \< or \>…
Interventions
- OtherWear clothing that has been exposed to cigarette smoke for 3 hours.
Cotton clothing is exposed to smoke from Marlboro Red (hard pack) cigarettes at 1-1.2 mg/m3 repeatedly, until total exposure equals 3 grams total particulate material. When tested after exposure, the clothing typically contained 59.15 +/- 18 µg nicotine and 42 +/- 24 ng NNK per gram. The mass of the clothing varies by size, but the average combination of pants and shirt contains 32 mgs nicotine and 23 µg NNK.
Location
- Zuckerberg San Francisco General HospitalSan Francisco, California