Prenatal Sonographic Prediction of Placental Histology and Function
Endeavor Health
Summary
The purpose of this two-phase observational study is to investigate the use of ultrasonography to predict placental pathology at the time of delivery.
Description
Placenta pathology is examined at the time of delivery and can show the underlying pathophysiology of adverse pregnancy outcomes. The Amsterdam consensus has identified four primary categories of injury, acute inflammation, fetal vascular malperfusion, maternal vascular malperfusion, and chronic inflammation associated with adverse obstetric outcomes. Findings from placental pathologic examination performed at delivery can reveal important patterns of injury that lead to adverse pregnancy outcomes but cannot aid in preventing these outcomes. Ultrasound of the placenta may be able to detect pla…
Eligibility
- Age range
- 18–60 years
- Sex
- Female
- Healthy volunteers
- Yes
Retrospective Phase Inclusion criteria: * Patients with delivery in NorthShore University HealthSystem, * Ultrasound available within 4 weeks of delivery with adequate placental images * Placental pathology available Exclusion criteria: * Multiple gestation Prospective Phase Inclusion criteria * Exposed: Patients with singleton gestation with fetal growth restriction at 20-28 weeks with a plan to deliver at NorthShore Highland Park Hospital Evanston Hospital. Patients must have a first-trimester ultrasound (\<14 weeks) to confirm pregnancy dating available in the electronic medical recor…
Location
- NorthShore University HealthSystemEvanston, Illinois