Mayo Clinic
The purpose of this research is to further investigate the potential of brain stiffness as a novel biomarker for Alzheimer's disease.
Due to shifting demographics, the prevalence of dementia continues to increase in the population. To mitigate the effects of dementia will require new treatments working jointly with new methods for earlier and more sensitive diagnosis of the diseases. Magnetic resonance elastography (MRE) is a noninvasive technique for measuring tissue stiffness. MRE is a three-step process beginning with the introduction of shear waves into the tissue of interest with an external vibration source. The shear waves are imaged with a phase-contrast MRI pulse sequence and the resulting wave images are mathematic…
Inclusion Criteria for Control Subjects: * In good general health * No Active neurological or psychiatric conditions, if a prior neurological or psychiatric condition was present they must have returned to normal * No cognitive complaints * Normal neurological examination * No psychoactive medications * They may have a chronic medical condition that does not affect cognition * Low Aβ load Pittsburgh compound-B (PiB) ratio \<1.5 Inclusion Criteria for Mild Cognitive Impairment Subjects: * In good general health * Memory complaint documented by the patient and collateral source * Normal gener…
Imaging technique performed on a Compact 3T MRI scanner that measures the stiffness (mechanical properties) of tissues.
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