Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability
University of Texas Southwestern Medical Center
Summary
Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern. Nevertheless, the optimal approach for patient selection based on conventional imaging scans remains unclear. The proposed method (Hyperpolarized 13C MRI) has gained extensive use in evaluating in vivo metabolism. This method avoids ionizing radiation and provides critical insights into cardiac function. The feasibility study aims to investigate this method for patient selection before bypass surgery. This innovative imaging technique facilitates the identification of two simple molecules, bicarbonate and lactic acid, produced at high rates by normal heart metabolism. Both bicarbonate and lactate originate from the same precursor molecule, pyruvate. The data generated from this study holds the potential to refine diagnostic precision.
Description
PRIMARY OBJECTIVES: The principal aim of this investigation is to employ noninvasive techniques for the in vivo assessment of segmental myocardial metabolism. This will be achieved by measuring the hyperpolarized (HP) 13C bicarbonate-to-lactate (bic/lac) ratio in patients scheduled for coronary artery bypass surgery (CABG), both preoperatively and 4-6 months postoperatively. These findings will be compared with a control group of healthy subjects to establish normal metabolic values. SECONDARY OBJECTIVES: In addition to the primary objectives, this study seeks to accomplish the following se…
Eligibility
- Age range
- 20–80 years
- Sex
- All
- Healthy volunteers
- Yes
The eligibility criteria for this feasibility study are designed to select participants who will provide valuable insights into myocardial metabolism using HP-13C MRI in various contexts related to ischemic heart failure. These criteria aim to ensure that the study population is diverse and representative of the patient groups under investigation. Inclusion/Exclusion Criteria: * Age range: 20 to 80 years * Sex: Random allocation * Left ventricular ejection fraction (LVEF): * Preoperative patients with LVEF \< 0.35 * Healthy subjects with LVEF \> 0.50 * Clinical history: * Previous myocardial…
Location
- University of Texas Southwestern Medical CenterDallas, Texas