St. Louis University
This research will involve a prospective study on infection rates after grade 1 or 2 open fractures in the skeletally immature pediatric population. There will be 3 arms: one dose intravenous cefazolin, 24 hours intravenous cefazolin, and 24 hours intravenous cefazolin plus 5 days of oral cephalexin.
Pediatric patients presenting with open fractures will be screened for eligibility at the time of presentation. Informed consent form discussion will take place within 8 hours of the patient's presentation, or before their second dose of antibiotics would be due (if randomized to group 2 or 3). Upon arrival to the ED with an open fracture (grade I or II), the patient is assessed and care is initiated based on patient presentation. Patients are given an IV for medication administration and receive the first dose of antibiotics (cefazolin) as soon as possible. This is standard of care. Treatme…
Inclusion Criteria: * Pediatric patients ages 0-17 years old * Skeletally immature patients, as confirmed by xray imaging evaluated by an orthopaedic surgeon * Patient as sustained a grade 1 or 2 open fracture within 24 hours of presentation * Physician plans to manage the fracture non-operatively Exclusion Criteria: * Patients 18 years or older * Skeletally mature patients, as as confirmed by xray imaging evaluated by an orthopaedic surgeon * Patients with grade 3 open fractures * Gross contamination of the fracture * Fracture requires surgery * Immunocompromised patients * Allergies to ce…
Intravenous dose(s).
Five days oral.
Arctuva estimate
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