University of Pittsburgh
The investigators aim to examine the effect of the ketogenic diet on brain activity, metabolism, and emotions in adults with Bipolar Disorder (BD).
The investigators hypothesize that a ketogenic diet will enhance levels of the ketone body β-Hydroxybutyrate (beta OHB), resulting in reduced mania/hypomania severity and predisposition to mania/hypomania in individuals with BD. To test this hypothesis in depth, the investigators will use a novel, multidisciplinary mechanistic study using multimodal neuroimaging, peripheral markers of mitochondrial metabolism, and participant-derived induced pluripotent stem cell (iPSC)-derived organoids.
Inclusion Criteria: All participants: * 18-40 years of age * Not following a ketogenic diet BD hypomanic group (n=30): * Meeting sex proportion: 50% female * Meeting diagnosis proportion: 50:50% Bipolar I: Bipolar II (BDI:II) (Diagnostic and Statistical Manual of Mental Disorders 5; DSM-5) * Score greater than 10 on the Young Mania Rating Scale score(YMRS) * BD medications will be allowed as in our previous studies: any combination of atypical antipsychotics, lithium, antidepressants, anxiolytics (common in BD) BD euthymic group (n=30): * Meeting sex proportion: 50% female * Meeting diag…
Consuming a non-ketogenic diet
Consuming a ketogenic diet
Participants without Bipolar Disorder will not participate in the diet phases of the study
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