Metabolic and Physiologic Responses to Hormone Therapy in Transgender and Gender Diverse People
Mayo Clinic
Summary
The primary purpose of this research is to determine how gender affirming hormone therapy affects muscle physiology.
Description
Study participation involves a screening visit and two study visits. The screen includes blood draws, and urine testing. The first visit requires a collection of breath, exercise testing, and body scans. Between visits participant are to eat three days of provided meals and wear an activity monitor. The second study visit will be 3-14 days after the first and includes blood draws, a meal test, and a muscle biopsy. If individuals are not on gender affirming hormone therapy at the time of participation, they may be able to participate again if you decide to pursue gender affirming hormone therap…
Eligibility
- Age range
- 18–40 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * age 18-40yrs * BMI 18.5-38 kg/m2 * Fasting glucose \< 100 mg/dL * No gender affirming gonadal surgery We seek to enroll 6 patients in each group who have been on GAHT for more than 10 months with minimal interruptions in treatment. Exclusion Criteria: * Pregnancy * Use of hormonal forms of birth control within the previous 3 months * Use of glucocorticoids, estradiol, testosterone, progestin, antiandrogens, or antiestrogens besides those received as part of a supervised hormone therapy. * Gender-affirming gonadal surgery * Prior use of gonadotropin releasing hormone (…
Interventions
- Behavioralhormone therapy
Determine how gender affirming hormone therapy affects muscle physiology
Location
- Mayo ClinicRochester, Minnesota