Feasibility and Safety of Single Dose Ketamine for Acutely Suicidal Patients in the Emergency Department
Lindsay Maguire, MD
Summary
There is currently no readily available pharmacologic intervention for suicidal ideation, a true psychiatric emergency, in the Emergency Department (ED). Investigators aim to trial low-dose, intravenous ketamine, a drug with well-established use in treatment-resistant depression, for patients who present to the ED with suicidal ideation.
Description
In this phase one trial, the investigators' objective is to establish the safety and feasibility of the study dose and route of administration, as well as to provide preliminary data on efficacy in reduction of depressive and suicidal symptoms as well as length of stay. Select patients will be given 0.2mg/kg of ketamine IV and observed in the ED for two hours. Vital signs and symptoms will be monitored. Patients will then be transferred to an admitting psychiatric hospital for definitive care as per standard of care. Surveys will be administered at times 0, 2 hours, 24 hours, and 72 hours to a…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Acutely Suicidality ("yes" answer to any of items 4 or 5 on C-SSRS "Suicidal Ideation" category) * Require inpatient stabilization for SI or actions based on clinical observation and interview * Are accepted for psychiatric stabilization at the University of Kansas Medical Center's Strawberry Hill campus * Have a Glasgow Coma Score (GCS) of 15 * Age 18-65 Exclusion Criteria: * Current or past history of psychosis * Current or recent (past 4 weeks) symptoms of mania/hypomania as defined by Young Mania Rating Scale (YRMS) score of 12 or greater * History of ketamine use…
Interventions
- DrugKetamine
Patients will receive 0.2mg/kg of IV ketamine
Locations (2)
- University of Kansas Strawberry Hill CampusKansas City, Kansas
- University of Kansas Medical Center Emergency DepartmentKansas City, Kansas