Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
Laureate Institute for Brain Research, Inc.
Summary
This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute exercise in 20 participants with bipolar depression. Participants will complete four experimental sessions, two with an exercise challenge and two with a resting control condition in a counterbalanced order. Participants will receive either 800mg of ibuprofen or placebo before exercise or rest in order to test whether blocking the inflammatory response to exercise interferes with the neural and psychological effects of exercise.
Eligibility
- Age range
- 18–55 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Has an established residence and phone 3. Agrees to and is eligible for behavioral testing, magnetic resonance imaging, and blood draws. 4. Stated willingness to comply with all study procedures and lifestyle considerations (see Section 5.3, Lifestyle Considerations) and availability for the duration of the study 5. Males and females; Age 18-55 years 6. DSM-V diagnosis of bipolar disorder 7. Has a current major depressive episode 8. Depression at enrollment of sufficient severity to score \> 11 on the QIDS 9. Be sta…
Interventions
- OtherExercise Session
30 min cycling on bicycle ergometer at 60% peak power output
- DrugIbuprofen 800 mg
A single oral dose of Ibuprofen
- OtherRest
Resting for 30 min in chair
- DrugPlacebo
Matched placebo
Location
- Laureate Institute for Brain ResearchTulsa, Oklahoma