Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression

Summary

This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute exercise in 20 participants with bipolar depression. Participants will complete four experimental sessions, two with an exercise challenge and two with a resting control condition in a counterbalanced order. Participants will receive either 800mg of ibuprofen or placebo before exercise or rest in order to test whether blocking the inflammatory response to exercise interferes with the neural and psychological effects of exercise.

Eligibility

Age range

18–55 years

Sex

All

Healthy volunteers

No

Interventions

• Other
  Exercise Session

  30 min cycling on bicycle ergometer at 60% peak power output

• Drug
  Ibuprofen 800 mg

  A single oral dose of Ibuprofen

• Other
  Rest

  Resting for 30 min in chair

• Drug
  Placebo

  Matched placebo

Location