Children's Hospital Medical Center, Cincinnati
The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants in a Level IV Neonatal Intensive Care Unit (NICU) between two lighting environments. Investigators are seeking to learn whether supplementing the lighting environment of infants in the NICU with blue and violet wavelengths of light will allow more efficient utilization of the nutrition provided to participants by influencing hormones involved in regulation of growth and development as compared to a conventional lighting environment. Pre-clinical studies suggest that violet and blue wavelengths of light are involved in molecular pathways that help regulate metabolic activity.
Inclusion Criteria: * greater than or equal to 32 weeks post-menstrual age (PMA) * have an anticipated CCHMC NICU stay of at least 4 weeks following initiation of study participation Exclusion Criteria: * Infants with aneuploidy (having an abnormal amount of chromosomes) or other lethal congenital anomaly * Infants \<32 weeks post-menstrual age (PMA) * Infants actively receiving dialysis, extracorporeal membrane oxygenation (ECMO) or dependent on any ventricular assist device
Spectral room lighting containing violet and blue wavelengths of light capable of stimulating non-visual opsins including OPN5 and OPN3.
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