Addictive Threshold of Nicotine
Yale University
Summary
To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence.
Description
The purpose of this project is to determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, and reinforcement in smokers with different levels of dependence. Participants will have an Adaptation Session followed by 4 Test Days. The Adaptation Session will familiarize the participants with study procedures. In each Test Day, a different nicotine dose (0.1, 0.05, 0.025, and 0.0125 mg nicotine/pulse) will be compared to saline for nicotine discrimination, subjective effects, and reinforcement. Participants will first sample the assigned nicotine dose and saline, f…
Eligibility
- Age range
- 21–59 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * to contact their primary care provider when necessary. * Adults, aged 21 to 59 years. Individuals less than 21 will be excluded because the minimum age for purchasing tobacco products is 21 in our state. The upper age is set at 59 because there are no previous IV nicotine studies that enrolled smokers over the age of 59. * Smoking at least for one year and more frequently than once a week, smoking status confirmed with a semi-quantitative urine nicotine test. Smokers will be stratified based on the level of dependence, assessed with the FTND scores (Heatherton et al. 199…
Interventions
- DrugNicotine
Nicotine will be infused using a pump.
- OtherSaline
Saline with be used to compare Nicotine, Saline will be infused using a pump
Location
- VA Healthcare SystemWest Haven, Connecticut