Yale University
The International Post-Stroke Epilepsy Research Repository (IPSERR): The study aims to collate and categorize data reported by post-stroke epilepsy (PSE) researchers and lodge it within the IPSERR. Using the IPSERR database, we will conduct two individual patient data (IPD) analyses: (1) determine epilepsy, functional, and cognitive outcomes in stroke patients who develop post-stroke seizure and (2) build and validate post-stroke epilepsy prediction model and compare performance against existing models.
The cerebrovascular disease is the most common cause of late-onset epilepsy. PSE is associated with increased morbidity, including cognitive decline, dependence, and poor quality of life, and is a critical determinant factor of stroke prognosis. We recently reported a systematic review and meta-analysis of 71 papers that suggested that post-stroke seizures are associated with more significant mortality and poor functional and cognitive outcomes (PMID:37721736). In this study, we observed disparate methods used by the individual investigators. We also noted variations in study reporting. PI aim…
Inclusion Criteria: * Studies with minimum dataset of 100 patients * Studies comprising stroke patients aged ≥18 years, with ischemic or hemorrhagic stroke, presenting early or late PSS with data on patient outcome measures. * Documented consent or waiver of consent following local Institutional Review Board-approved procedure. * Studies published on human subjects. * No restriction based on the date or language of publication, gender, or ethnicity. Exclusion Criteria: * Studies of patients with a prior history of seizures before the index stroke, * Studies that did not report outcome data,…
Presence of ischemic or hemorrhagic stroke confirmed by neuroimaging and clinical diagnosis
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