H. Lee Moffitt Cancer Center and Research Institute
The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.
Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * ECOG performance status of 0, 1 * Patients with histologically or cytologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, or unknown primary in the neck. * Patients with measurable disease, either at primary site or neck per RECIST 1.1. * For patients planned to receive chemotherapy, adequate hematologic, hepatic and renal function as outlined in protocol. *…
All patients will be treated with intensity-modulated radiotherapy (IMRT) plans.
All patients will undergo combined CT and/or MR simulation and will be treated with a sequential-boost technique.
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