Phase 2 Trial of Adaptive Radiotherapy Boost for Head and Neck Squamous Cell Carcinomas
H. Lee Moffitt Cancer Center and Research Institute
Summary
The purpose of the study is to determine if it is feasible to use magnetic resonance imaging (MRI) to adjust a portion of radiation therapy for patients with head and neck squamous cell carcinoma . The technique under study will be used to personalize the study treatment based on response, keeping all treatments within standard of care guidelines.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * ECOG performance status of 0, 1 * Patients with histologically or cytologically confirmed squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, or unknown primary in the neck. * Patients with measurable disease, either at primary site or neck per RECIST 1.1. * For patients planned to receive chemotherapy, adequate hematologic, hepatic and renal function as outlined in protocol. *…
Interventions
- RadiationIntensity-modulated radiotherapy
All patients will be treated with intensity-modulated radiotherapy (IMRT) plans.
- OtherMagnetic Resonance Guidance
All patients will undergo combined CT and/or MR simulation and will be treated with a sequential-boost technique.
Location
- Moffitt Cancer CenterTampa, Florida